TITRE: Bidentate, Monoanionic Directing Groups for Carbon-Hydrogen Bond Functionalization
RESUME
In last few decades, carbon-hydrogen bond functionalization has matured from an academic curiosity in organometallic chemistry to widespread applications in synthesis of complex natural products and drugs.1 Carbon-hydrogen bonds are the most abundant functionality in organic molecule and their use as a functional group for further conversions allows shortening of synthetic pathways. This saves reagents, solvents, and decreases labor costs. Since the amount of generated chemical waste is decreased, positive impact of this chemistry on environment is achieved. This talk will describe the work in our group that led to the development of bidentate, monoanionic directing groups for carbon-hydrogen bond functionalization under palladium, cobalt, and copper catalysis. A few extensions of this chemistry will also be discussed.
References
- Daugulis, O.; Roane, J.; Tran, L. D. Chem. Res. 2015, 48, 1053-1064.
