Prix: Gratuit
Amphithéâtre Justine-Lacoste-Beaubien
3175, Chemin de la Côte-Sainte-Catherine
Montréal (QC) Canada  H3T 1C5

Conférence scientifique | Centre de recherche du CHU Sainte-Justine

Conférence de Jasmin Coulombe-Huntington, PhD, stagiaire postdoctoral, Institut de recherche en immunologie et en cancérologie (IRIC), Université de Montréal.

Résumé :
Genome-wide CRISPR/Cas9 knockout screens can reveal genotype-to-phenotype relationships and mechanisms of resistance and sensitization to drugs and other compounds. We have undertaken more than 250 CRISPR/Cas9 screens to map these relationships. I will present a plan to apply network-based approaches to model fitness effects of gene knockouts to predict drug mechanisms, gene functions, cancer-specific vulnerabilities and synergistic drug combinations.  I will also cover earlier work on the network-level effects of alternative splicing and disease variants and present a machine learning-based strategy to reconstruct signaling pathways mediated by short linear motifs in disordered protein regions.

From Point Mutations to Genome-scale Models: A Network Perspective
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