Titre :Post-Alkylation of a Common mPEG-b-PAGE Precursor to Produce Tunable Morphologies of Spheres, Filomicelles, Disks and Polymersomes for Applications in Drug Delivery
Endroit : Pavillon Roger-Gaudry, salle S-142 à 10 h.
Hôte : Julian Zhu
La conférence sera prononcée par Frantz Le Dévédec Ph.D., ancien étudiant du Groupe du Prof. Julian Zhu.
Résumé : The facile preparation of biocompatible materials that self-assemble into nanostructures of well-defined morphology is of keen interest to the biomedical community. The mPEG-b-PAGE copolymer was then used as a common precursor to generate a systematic series of copolymers derivatized with pendant alkyl chains via thiolene click chemistry. Polyalkylated copolymers based on mPEG-b-(AGE-C6,12 or 18)25 have been used to formulate clinically relevant concentrations of doxorubicin (DOX) and the impact of drug incorporation on copolymer aggregation behaviour was examined. The copolymer aggregates were analyzed by various microscopy techniques (TEM, cryo-TEM and AFM) and scattering methods (SANS, DLS). In the absence of drug, the copolymers formed largely non-spherical aggregates (i.e. cylinders, vesicles). DOX incorporation had a striking impact on the morphology of the PCAs. As well, the nature of the core-forming block was found to influence drug release and cytotoxicity of the formulations. The promising preliminary assessment of these alkylated copolymers encourages additional evaluation in vivo.
