Titre : New Technologies for Ultrasensitive Analysis of Clinically-Relevant Biomolecules.
Endroit : Pavillon Roger-Gaudry, salle G-615 à 11 h.
Hôte : Professeur Alexis Vallée-Bélisle.
Cette conférence sera prononcée (en anglais) par la professeure Shana Kelley du Département de biochimie de l'University of Toronto.
Résumé : Advances in genomic and proteomic methods now allow classification of disease based on molecular profiling. The detection of a molecular analytes and use of this type of information for disease diagnosis requires methods with superior sensitivity and specificity, along with high-throughput. We are developing new analytical methods with these properties that will permit the direct readout of nucleic acid sequences and protein biomarkers. Novel technologies for ultrasensitive DNA, RNA, and protein sensing have been developed in our laboratories that use electrochemical methods for readout. Chip-based sensors made from nanomaterials play an important role in this effort, as detection sensitivity is greatly enhanced when measurements are performed at the nanoscale. We have also recently developed devices that capture rare cells with high efficiency. Our aim is to generate detection systems applicable to the diagnosis of cancer, infectious disease and other disease states. Members of this project team fabricate devices, develop reporter assays and work with biological and clinical samples to validate new technologies.
