Titre : Mass Spectrometry-Led Catalyst Discovery.
La conférence sera prononcée par le professeur Scott McIndoe du Département de chimie de l'University of Victoria. Elle sera donnée en anglais.
Résumé : Determination of catalytic mechanisms is a challenging task, not least because intermediates are difficult to observe due to their relatively low concentration. Electrospray ionization mass spectrometry has some distinct advantages in this regard: it is fast, highly sensitive and has a wide dynamic range, allowing the simultaneously monitoring of the concentration of starting materials, products, byproducts and intermediates. However, the technique has numerous weaknesses that must be overcome through the application of appropriate methodology. Our approach will be described in the context of our investigations into palladium-catalyzed cross-coupling reactions, including the copper-free Sonogashira and Suzuki reactions.
