Titre : Harnessing the Reactivity of Azides with Transition Metal Complexes.
La conférence sera prononcée par le professeur Tom Driver du Département de chimie de l'University of Illinois at Chicago. Elle sera donnée en anglais.
Résumé : As part of a program aimed at the discovery of new metal-mediated reactions, we found that aromatic N-heterocycles can be synthesized from vinyl- or aryl azides using transition metal catalysts to mediate C–N bond formation. Using transition metal catalysts, we have successfully constructed a range of N-heterocycles, whose motifs are present in biologically relevant small molecules. From a fundamental view, our research has established new reactivity patterns for transition metal reagents and azides, where the mechanism for C–N bond formation depends on the structure of the azide and identity of the catalyst.
