Conférence scientifique de l'Unité collaborative en épigénétique moléculaire (UCEM)
Conférence de Mathieu Lupien, PhD, Assistant Professor, Department of Medical Biophysics, Princess Margaret Cancer Centre/University Health Network University of Toronto.
Résumé :
Cancer development is commonly ascribed to genetic alterations, whether inherited or acquired. These commonly promote epigenetic reprogramming to induce transcriptional programs favorable to dedifferentiation and long-term self-renewal. However, cancer can also arise independently of genetic alterations. For instance, pediatric ependymomas are free of recurrent genetic alterations. Yet, they harbor epigenetic changes that drive tumor growth. In this presentation, we will explore the intricate relationship between genetic alterations and epigenetic reprogramming in prostate cancer and present alternative mechanisms from our recent work in breast cancer that supports epigenetic reprogramming independently of genetic alterations.
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